Methylamine → 5-Bromo-N-methylpyrimidin-2-amine

40% Aqueous methylamine solution (35 ml) and methanol (20 ml) were added to 5-bromo-2-chloropyrimidine (3 μg, 15.5 mmol) and the resulting mixture was heated to reflux for 3 days. The mixture was cooled, then the solvent was evaporated under reduced pressure, the residue was partitioned with methylene chloride and 1 M sodium hydroxide, the organic layer was dried over magnesium sulfate, and the solvent was evaporated under reduced pressure to give the title compound (3.0 g, 100%) as a white solid.

1. temperaturethe resulting mixture was heated
2. temperatureto reflux for 3 days
3. temperatureThe mixture was cooled
4. customthe solvent was evaporated under reduced pressure
5. customthe residue was partitioned with methylene chloride and 1 M sodium hydroxide
6. dry with materialthe organic layer was dried over magnesium sulfate
7. customthe solvent was evaporated under reduced pressure

ORD record

ord-7653f04a989846929be02fc0670fa8bf

Source dataset

uspto-grants-2012_11

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US08309546B2