反应详情

An ethanol (5 ml) solution of 2,6-dichloro-9H-purine (187 mg, 0.99 mmol), (S)-3-methyl-morpholine (100 mg, 0.99 mmol), and N,N-diisopropylethylamine (252 μl, 1.48 mmol) was heated to reflux for 15 hours. The reaction mixture was returned to room temperature and concentrated under reduced pressure. The residue was purified by flash silica gel column chromatography (methylene chloride:methanol=98:2 to 97:3) to give the title compound (132 mg, 53%) as a solid.

1. temperatureto reflux for 15 hours
2. customwas returned to room temperature
3. concentrationconcentrated under reduced pressure
4. customThe residue was purified by flash silica gel column chromatography (methylene chloride:methanol=98:2 to 97:3)