4-(4-Aminophenyl)morpholin-3-one → HCID 58014395, compound

HRID 1876860Notes

Reaction equation

HRID 1876860 reaction equation
Cl[C:2]1[N:7]=[C:6]([C:8]2[CH:9]=[N:10][N:11]([CH:13]([CH2:28][C:29]#[N:30])[CH2:14][CH:15]3[CH2:20][CH2:19][N:18](C(OC(C)(C)C)=O)[CH2:17][CH2:16]3)[CH:12]=2)[CH:5]=[CH:4][N:3]=1.[NH2:31][C:32]1[CH:37]=[CH:36][C:35]([N:38]2[CH2:43][CH2:42][O:41][CH2:40][C:39]2=[O:44])=[CH:34][CH:33]=1>>[O:44]=[C:39]1[N:38]([C:35]2[CH:34]=[CH:33][C:32]([NH:31][C:2]3[N:7]=[C:6]([C:8]4[CH:9]=[N:10][N:11]([CH:13]([CH2:14][CH:15]5[CH2:20][CH2:19][NH:18][CH2:17][CH2:16]5)[CH2:28][C:29]#[N:30])[CH:12]=4)[CH:5]=[CH:4][N:3]=3)=[CH:37][CH:36]=2)[CH2:43][CH2:42][O:41][CH2:40]1

Participants

3

Reactant 2

HCID 111948544-(4-Aminophenyl)morpholin-3-oneHCID 86637290HCID 86637290, compound

Product 1

HCID 58014395HCID 58014395, compound

Procedure

This compound was prepared as a racemic mixture, by coupling of tert-butyl 4-(2-(4-(2-chloropyrimidin-4-yl)-1H-pyrazol-1-yl)-3-cyanopropylpiperidine-1-carboxylate (from example 1, step 4) with 4-(4-aminophenyl)-3-morpholinone (from Affinitis Pharma) according to the procedure described in example 1, step 6. LCMS (M+H) 487.1.

Sources & evidence

ORD record
ord-43449259266e4dacb4bfb1c7f01b52f7
Source dataset
uspto-grants-2012_11
Patent number
US08309718B2

Reaction notes

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