反应详情

A mixture of 3-(4-(2-chloropyrimidin-4-yl)-1H-pyrazol-1-yl)-3-(cyanomethyl)-cyclobutanecarbonitrile (300 mg, 0.00100 mol), p-aminobenzoic acid (206 mg, 0.00151 mol), and p-toluenesulfonic acid (150 mg, 0.00085 mol) in dry 1,4-dioxane (8 mL) was refluxed overnight, cooled to room temperature. The solid was filtered and collected to give the titled compound as a cis- and trans-isomer mixture, which was used directly in next step (310 mg, 77.3%). LCMS (M+H) 400.4.

1. temperaturewas refluxed overnight
2. filtrationThe solid was filtered
3. customcollected