反应详情

温度

40 °C

A suspension of {2-ethyl-5-[4-(trifluoromethyl)phenyl]-3-furyl}methanol (2.7 g) and manganese dioxide (6.8 g) in diethyl ether (20 mL) and tetrahydrofuran (20 mL) was stirred overnight at 40° C. Manganese dioxide was filtered off, and the filtrate was evaporated under reduced pressure. The residue was purified by silica gel chromatography (5% ethyl acetate/hexane to 20% ethyl acetate/hexane), and crystallized from ethyl acetate/hexane to give the title compound (0.66 g, 24%) as a yellow solid.

1. filtrationManganese dioxide was filtered off
2. customthe filtrate was evaporated under reduced pressure
3. customThe residue was purified by silica gel chromatography (5% ethyl acetate/hexane to 20% ethyl acetate/hexane)
4. customcrystallized from ethyl acetate/hexane