Ethyl 3-cyclohexyl-3-oxopropanoate → Ethyl 2-cyclohexyl-5-[4-(trifluoromethyl)phenyl]-3-furoate

HRID 1876946Notes

Reaction equation

HRID 1876946 reaction equation
Cl[CH2:2][C:3]([C:5]1[CH:10]=[CH:9][C:8]([C:11]([F:14])([F:13])[F:12])=[CH:7][CH:6]=1)=[O:4].[CH:15]1([C:21](=O)[CH2:22][C:23]([O:25][CH2:26][CH3:27])=[O:24])[CH2:20][CH2:19][CH2:18][CH2:17][CH2:16]1>>[CH:15]1([C:21]2[O:4][C:3]([C:5]3[CH:10]=[CH:9][C:8]([C:11]([F:14])([F:13])[F:12])=[CH:7][CH:6]=3)=[CH:2][C:22]=2[C:23]([O:25][CH2:26][CH3:27])=[O:24])[CH2:20][CH2:19][CH2:18][CH2:17][CH2:16]1

Participants

3

Reactant 2

HCID 266327Ethyl 3-cyclohexyl-3-oxopropanoateHCID 127899772-Chloro-1-[4-(trifluoromethyl)phenyl]ethan-1-one

Product 1

HCID 68511169Ethyl 2-cyclohexyl-5-[4-(trifluoromethyl)phenyl]-3-furoateYield 42.1%

Procedure

An operation similar to that in Example 1 (1) was performed using 2-chloro-4′-(trifluoromethyl)acetophenone (13.4 g) and ethyl 3-cyclohexyl-3-oxopropanoate (9.9 g) to give the title compound (7.7 g, 40%) as a yellow crystal.

Sources & evidence

ORD record
ord-4687f40e83ed42df88a907045d73de81
Source dataset
uspto-grants-2012_11
Patent number
US08309580B2

Reaction notes

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