HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl 3-cyclohexyl-3-oxopropanoate → Ethyl 2-cyclohexyl-5-[4-(trifluoromethyl)phenyl]-3-furoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl 3-cyclohexyl-3-oxopropanoate | HCID 266327 | — |
| Reactant | 2-Chloro-1-[4-(trifluoromethyl)phenyl]ethan-1-one | HCID 12789977 | — |
| Product | Ethyl 2-cyclohexyl-5-[4-(trifluoromethyl)phenyl]-3-furoate | HCID 68511169 | 42.1% |
Reaction Steps
An operation similar to that in Example 1 (1) was performed using 2-chloro-4′-(trifluoromethyl)acetophenone (13.4 g) and ethyl 3-cyclohexyl-3-oxopropanoate (9.9 g) to give the title compound (7.7 g, 40%) as a yellow crystal.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08309580B2 |
| Source dataset | uspto-grants-2012_11 |
| ORD ID | ord-4687f40e83ed42df88a907045d73de81 |
| Source note | uspto-grants-2012_11 |