反应详情

To a mixture of methyl 4-[cyclohexyl(5-cyclohexyl-2-ethylthiophen-3-yl)methoxy]benzoate (560 mg) synthesized above, tetrahydrofuran (10 mL) and ethanol (10 mL) was added 1N aqueous sodium hydroxide solution (5 mL), and the mixture was stirred with heating under reflux overnight. The reaction mixture was concentrated under reduced pressure, 1N hydrochloric acid was added, and the mixture was extracted with ethyl acetate. The extract was washed with brine, dried over magnesium sulfate and concentrated under reduced pressure to give a white solid. The obtained solid was recrystallized from ethyl acetate-hexane to give the title compound (194 mg, 36%) as a colorless crystal.

1. temperaturewith heating
2. temperatureunder reflux overnight
3. concentrationThe reaction mixture was concentrated under reduced pressure, 1N hydrochloric acid
4. additionwas added
5. extractionthe mixture was extracted with ethyl acetate
6. washThe extract was washed with brine
7. dry with materialdried over magnesium sulfate
8. concentrationconcentrated under reduced pressure
9. customto give a white solid
10. customThe obtained solid was recrystallized from ethyl acetate-hexane