HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tetrahydrothiopyran-4-one → ethyl 2-ethyl-5-(4-hydroxytetrahydro-2H-thiopyran-4-yl)thiophene-3-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tetrahydrothiopyran-4-one | HCID 66173 | — |
| Reactant | Ethyl 5-bromo-2-ethylthiophene-3-carboxylate | HCID 68515411 | — |
| Product | ethyl 2-ethyl-5-(4-hydroxytetrahydro-2H-thiopyran-4-yl)thiophene-3-carboxylate | HCID 68512008 | 73% |
Reaction Steps
An operation similar to that in Example 73 (1) was performed using ethyl 5-bromo-2-ethylthiophene-3-carboxylate (5.00 g) synthesized in Example 69 (4) and tetrahydro-4H-thiopyran-4-one (6.62 g) to give the title compound (4.16 g, 73%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08309580B2 |
| Source dataset | uspto-grants-2012_11 |
| ORD ID | ord-3b06dd67e304426fb89522f43681b822 |
| Source note | uspto-grants-2012_11 |