Thionyl Chloride → HCID 68514193, compound

HRID 1877022Notes

Reaction equation

HRID 1877022 reaction equation
[CH:1]1([CH:7]([C:9]2[CH:13]=[C:12]([C:14]3[CH:15]=[N:16][CH:17]=[CH:18][CH:19]=3)[O:11][C:10]=2[CH3:20])O)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.S(Cl)([Cl:23])=O>C1(C)C=CC=CC=1>[Cl:23][CH:7]([CH:1]1[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1)[C:9]1[CH:13]=[C:12]([C:14]2[CH:15]=[N:16][CH:17]=[CH:18][CH:19]=2)[O:11][C:10]=1[CH3:20]

Participants

4

Reactant 2

HCID 24386Thionyl ChlorideHCID 68507584HCID 68507584, compound

Product 1

HCID 68514193HCID 68514193, compoundYield 100%

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

To a solution of cyclohexyl[2-methyl-5-(pyridin-3-yl)furan-3-yl]methanol (1.6 g) in toluene (20 mL) was added thionyl chloride (1.3 mL), and the mixture was stirred at room temperature for 4 hr. The solvent was evaporated under reduced pressure to give the title compound (1.7 g, 100%) as an amorphous compound.

Workup

  1. customThe solvent was evaporated under reduced pressure

Sources & evidence

ORD record
ord-c1fbc15b29ca4dccbdefcb85694993da
Source dataset
uspto-grants-2012_11
Patent number
US08309580B2

Reaction notes

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