Methanol → Methyl 3-amino-2-hydroxypropanoate hydrochloride

Participants

Reaction Conditions

Reaction Steps

To a solution of 3-amino-2-hydroxypropanoic acid (0.7 g) in methanol (15 mL) was added thionyl chloride (2.5 mL) at 0° C., and the mixture was stirred at 0° C. for 2 hr and then at room temperature overnight. The solvent was evaporated under reduced pressure to give the title compound (1.6 g, 100%) as an oil.

Provenance & Evidence