Sodium ion → 4-(4-Bromo-phenyl)-4-hydroxymethyl-piperidine-1-carboxylic acid tert-butyl ester

HRID 187708Notes

Reaction equation

HRID 187708 reaction equation
[BH4-:24].[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH2:10][C:11]([CH2:14][CH:15]=[O:16])([c:17]2[cH:18][cH:19][c:20]([Br:23])[cH:21][cH:22]2)[CH2:12][CH2:13]1.[CH:26]([CH3:27])([CH3:28])[OH:29].[Na+:25]>>[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH2:10][C:11]([c:17]2[cH:18][cH:19][c:20]([Br:23])[cH:21][cH:22]2)([CH2:26][OH:29])[CH2:12][CH2:13]1

Participants

5

Reactant 4

HCID 923Sodium ionHCID 3776IsopropanolHCID 28123BorohydrideHCID 86596808HCID 86596808, compound

Product 1

HCID 576031994-(4-Bromo-phenyl)-4-hydroxymethyl-piperidine-1-carboxylic acid tert-butyl ester

Sources & evidence

ORD record
ord-3dc5b946df6f491fa799d2515e3b1a89
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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