Thionyl Chloride → HCID 68509793, compound

HRID 1877229Notes

Reaction equation

HRID 1877229 reaction equation
[CH:1]1([CH:7]([C:9]2[S:10][C:11]([C:15]3[CH:20]=[CH:19][C:18]([C:21]([F:24])([F:23])[F:22])=[CH:17][CH:16]=3)=[CH:12][C:13]=2[CH3:14])O)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.S(Cl)([Cl:27])=O>C1(C)C=CC=CC=1>[Cl:27][CH:7]([CH:1]1[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1)[C:9]1[S:10][C:11]([C:15]2[CH:20]=[CH:19][C:18]([C:21]([F:24])([F:23])[F:22])=[CH:17][CH:16]=2)=[CH:12][C:13]=1[CH3:14]

Participants

4

Reactant 2

HCID 24386Thionyl ChlorideHCID 68511337HCID 68511337, compound

Product 1

HCID 68509793HCID 68509793, compoundYield 100%

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

To a solution of cyclohexyl{3-methyl-5-[4-(trifluoromethyl)phenyl]thiophen-2-yl}methanol (1.3 g) in toluene (20 mL) was added thionyl chloride (0.4 mL), and the mixture was stirred at room temperature for 2 hr. The solvent was evaporated under reduced pressure to give the title compound (1.3 g, 100%) as an amorphous compound.

Workup

  1. customThe solvent was evaporated under reduced pressure

Sources & evidence

ORD record
ord-6b78e72c6aad44bf97ba83b97b131f1a
Source dataset
uspto-grants-2012_11
Patent number
US08309580B2

Reaction notes

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