反应详情

A mixture of ethyl 3-[(4-nitrobenzoyl)amino]propanoate (26.6 g) synthesized above, 5% palladium-carbon (8.9 g), tetrahydrofuran (150 mL) and ethanol (150 mL) was stirred under a hydrogen atmosphere at room temperature overnight. 5% Palladium-carbon was filtered off, and the filtrate was concentrated under reduced pressure to give a white solid. Recrystallization from ethyl acetate-diisopropyl ether gave the title compound (22.6 g, 95%) as a white crystal.

1. filtration5% Palladium-carbon was filtered off
2. concentrationthe filtrate was concentrated under reduced pressure
3. customto give a white solid
4. customRecrystallization from ethyl acetate-diisopropyl ether