2,5-Dichlorophenol → HCID 46194843, compound

HRID 1877352Notes

Reaction equation

HRID 1877352 reaction equation
Cl[C:2]1[C:7]([C:8]([N:10]2[C:19]3[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=3)[CH2:13][CH2:12][CH2:11]2)=[O:9])=[CH:6][C:5]([Cl:20])=[CH:4][N:3]=1.ClC1C=C(O)C=CC=1.[Cl:29][C:30]1[CH:35]=[CH:34][C:33]([Cl:36])=[CH:32][C:31]=1[OH:37]>>[Cl:20][C:5]1[CH:6]=[C:7]([C:8]([N:10]2[C:19]3[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=3)[CH2:13][CH2:12][CH2:11]2)=[O:9])[C:2]([O:37][C:31]2[CH:32]=[C:33]([Cl:36])[CH:34]=[CH:35][C:30]=2[Cl:29])=[N:3][CH:4]=1

Participants

4

Reactant 3

HCID 662,5-DichlorophenolHCID 79333-ChlorophenolHCID 86641255HCID 86641255, compound

Product 1

HCID 46194843HCID 46194843, compound

Procedure

The title compound was prepared in analogy to Example 25, Step 2, replacing (2-chloro-5-fluoro-pyridin-3-yl)-(3,4-dihydro-2H-quinolin-1-yl)-methanon with (2,5-dichloro-pyridin-3-yl)-(3,4-dihydro-2H-quinolin-1-yl)-methanone and 3-chloro-phenol with 2,5-dichloro-phenol ([CAS RN 583-78-8]). MS (ISP): 433.2 [M+H]+.

Sources & evidence

ORD record
ord-c9b6d0df19694e4cbec4d6a4b9467eb1
Source dataset
uspto-grants-2012_11
Patent number
US08309734B2

Reaction notes

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