2,5-Dichlorophenol → HCID 46194845, compound

HRID 1877353Notes

Reaction equation

Cl[C:2]1[C:7]([C:8]([N:10]2[C:19]3[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=3)[CH2:13][CH2:12][CH2:11]2)=[O:9])=[CH:6][CH:5]=[C:4]([C:20]([F:23])([F:22])[F:21])[N:3]=1.ClC1C=C(O)C=CC=1.[Cl:32][C:33]1[CH:38]=[CH:37][C:36]([Cl:39])=[CH:35][C:34]=1[OH:40]>>[Cl:32][C:33]1[CH:38]=[CH:37][C:36]([Cl:39])=[CH:35][C:34]=1[O:40][C:2]1[C:7]([C:8]([N:10]2[C:19]3[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=3)[CH2:13][CH2:12][CH2:11]2)=[O:9])=[CH:6][CH:5]=[C:4]([C:20]([F:23])([F:22])[F:21])[N:3]=1

Participants

Reactant 3

HCID 662,5-Dichlorophenol

HCID 79333-Chlorophenol

HCID 86641256HCID 86641256, compound

Product 1

HCID 46194845HCID 46194845, compound

Procedure

The title compound was prepared in analogy to Example 25, Step 2, replacing (2-chloro-5-fluoro-pyridin-3-yl)-(3,4-dihydro-2H-quinolin-1-yl)-methanone with (2-chloro-6-trifluoromethyl-pyridin-3-yl)-(3,4-dihydro-2H-quinolin-1-yl)-methanone and 3-chloro-phenol with 2,5-dichloro-phenol ([CAS RN 583-78-8]). MS (ISP): 467.1 [M+H]+.

Sources & evidence

ORD record: ord-dbae1a7f628c4e9f91fd9a2480bb259c
Source dataset: uspto-grants-2012_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08309734B2

Reaction notes

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