Hydrochloric Acid → HCID 67292500, compound

HRID 1877703Notes

Reaction equation

HRID 1877703 reaction equation
[N:1]1[CH:6]=[CH:5][C:4]([C:7]2([NH:10]C(=O)OC(C)(C)C)[CH2:9][CH2:8]2)=[CH:3][N:2]=1.[ClH:18]>O1CCOCC1>[ClH:18].[N:1]1[CH:6]=[CH:5][C:4]([C:7]2([NH2:10])[CH2:9][CH2:8]2)=[CH:3][N:2]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 67292943HCID 67292943, compound

Product 1

HCID 67292500HCID 67292500, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

To a mixture of tert-butyl 1-(pyridazin-4-yl)cyclopropylcarbamate (0.100 g, 0.425 mmol, 1.0 eq) in a solution of 4.0 M HCl in 1,4-dioxane (4.0 ml) was stirred at r.t. for 5 hr. The reaction mixture was concentrated under vacuum and dried HCl salt was taken to next step.

Workup

  1. concentrationThe reaction mixture was concentrated under vacuum and dried HCl salt

Sources & evidence

ORD record
ord-941bc0f1488c480195a36ed07af0cc94
Source dataset
uspto-grants-2012_11
Patent number
US08309558B2

Reaction notes

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