反应详情

26.0 g (0.140 mol) of biphenyl-3,3′-diol and 10.0 g of 3-bromo-1-propanol are dissolved in 300 ml of acetone, and, after addition of 19.3 g (0.140 mol) of potassium carbonate, the mixture is heated under reflux overnight. The batch is subsequently filtered and evaporated, and the residue is chromatographed on silica gel with toluene/ethyl acetate (1:1), giving 3′-(3-hydroxypropoxy)biphenyl-3-ol as colourless crystals.

1. temperaturethe mixture is heated
2. temperatureunder reflux overnight
3. filtrationThe batch is subsequently filtered
4. customevaporated
5. customthe residue is chromatographed on silica gel with toluene/ethyl acetate (1:1)