HCID 58239621, compound → HCID 58239608, compound

HRID 1877710Notes

Reaction equation

HRID 1877710 reaction equation
C([O:8][C:9]1[CH:10]=[C:11]([C:15]2[CH:20]=[CH:19][CH:18]=[C:17]([CH2:21][CH2:22][CH2:23][OH:24])[CH:16]=2)[CH:12]=[CH:13][CH:14]=1)C1C=CC=CC=1>C1COCC1.[Pd]>[OH:24][CH2:23][CH2:22][CH2:21][C:17]1[CH:16]=[C:15]([C:11]2[CH:12]=[CH:13][CH:14]=[C:9]([OH:8])[CH:10]=2)[CH:20]=[CH:19][CH:18]=1

Participants

4

Reactant 1

HCID 58239621HCID 58239621, compound

Product 1

HCID 58239608HCID 58239608, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 8028TetrahydrofuranSolvent

Procedure

7.8 g (23.7 mmol) of 3-(3′-benzyloxybiphenyl-3-yl)propanol are hydrogenated to completion in THF on a palladium/activated carbon catalyst. The catalyst is filtered off, the filtrate is evaporated, and the residue is chromatographed on silica gel with toluene/ethyl acetate (2:1), giving 3′-(3-hydroxypropyl)biphenyl-3-ol as a colourless oil.

Workup

  1. filtrationThe catalyst is filtered off
  2. customthe filtrate is evaporated
  3. customthe residue is chromatographed on silica gel with toluene/ethyl acetate (2:1)

Sources & evidence

ORD record
ord-cc3a9fb44aa9480eafb318e43f19cd4d
Source dataset
uspto-grants-2012_11
Patent number
US08313669B2

Reaction notes

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