4-Methylphenylhydrazine monohydrochloride → HCID 58345429, compound

HRID 1877979Notes

Reaction equation

HRID 1877979 reaction equation
[CH2:1]([O:3][C:4](=[O:20])[C:5](=O)/[CH:6]=[C:7](/[C:9]1[CH:14]=[CH:13][CH:12]=[C:11]([C:15]([F:18])([F:17])[F:16])[CH:10]=1)\[O-])[CH3:2].[Li+].Cl.[C:23]1([CH3:31])[CH:28]=[CH:27][C:26]([NH:29][NH2:30])=[CH:25][CH:24]=1>>[CH3:31][C:23]1[CH:28]=[CH:27][C:26]([N:29]2[C:7]([C:9]3[CH:14]=[CH:13][CH:12]=[C:11]([C:15]([F:18])([F:17])[F:16])[CH:10]=3)=[CH:6][C:5]([C:4]([O:3][CH2:1][CH3:2])=[O:20])=[N:30]2)=[CH:25][CH:24]=1

Participants

3

Reactant 2

HCID 125044-Methylphenylhydrazine monohydrochlorideHCID 58277291HCID 58277291, compound

Product 1

HCID 58345429HCID 58345429, compoundYield 67%

Procedure

Starting from 631.5 mg (2.15 mmol) of lithium (1Z)-4-ethoxy-3,4-dioxo-1-[3-(trifluoromethyl)phenyl]but-1-en-1-olate from example 1A and 463.2 mg (2.92 mmol) of 4-tolylhydrazine hydrochloride, 535.8 mg (1.4 mmol, 67% yield of theory) of product are obtained according the method described in example 4A.

Workup

  1. customare obtained

Sources & evidence

ORD record
ord-16f0358e196c4f8288c6f1a9e9b1961f
Source dataset
uspto-grants-2012_11
Patent number
US08314089B2

Reaction notes

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