3-Methoxyphenylhydrazine hydrochloride → HCID 58345415, compound

HRID 1877983Notes

Reaction equation

HRID 1877983 reaction equation
[CH2:1]([O:3][C:4](=[O:20])[C:5](=O)/[CH:6]=[C:7](/[C:9]1[CH:14]=[CH:13][CH:12]=[C:11]([C:15]([F:18])([F:17])[F:16])[CH:10]=1)\[O-])[CH3:2].[Li+].Cl.[CH3:23][O:24][C:25]1[CH:26]=[C:27]([NH:31][NH2:32])[CH:28]=[CH:29][CH:30]=1>>[CH3:23][O:24][C:25]1[CH:26]=[C:27]([N:31]2[C:7]([C:9]3[CH:14]=[CH:13][CH:12]=[C:11]([C:15]([F:18])([F:17])[F:16])[CH:10]=3)=[CH:6][C:5]([C:4]([O:3][CH2:1][CH3:2])=[O:20])=[N:32]2)[CH:28]=[CH:29][CH:30]=1

Participants

3

Reactant 2

HCID 27239403-Methoxyphenylhydrazine hydrochlorideHCID 58277291HCID 58277291, compound

Product 1

HCID 58345415HCID 58345415, compoundYield 85%

Procedure

Starting from 1.5 g (5.2 mmol) of lithium (1Z)-4-ethoxy-3,4-dioxo-1-[3-(trifluoro-methyl)phenyl]but-1-en-1-olate from example 1A and 1 g (5.73 mmol) of 3-methoxyphenylhydrazine hydrochloride, 1.73 g (4.4 mmol, 85% yield of theory) of product are obtained according to the method described in example 4A and after purification on silica gel (flash chromatography).

Workup

  1. customare obtained
  2. customafter purification on silica gel (flash chromatography)

Sources & evidence

ORD record
ord-0e82b067dd0249ac833c9c20a409212e
Source dataset
uspto-grants-2012_11
Patent number
US08314089B2

Reaction notes

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