Hexane → HCID 68490657, compound

HRID 1878002Notes

Reaction equation

HRID 1878002 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[NH:10][C:9](=[O:11])[O:8][C:7]([CH2:16][CH2:17][NH:18][C:19](=[O:27])[C:20]3[CH:25]=[CH:24][C:23]([F:26])=[CH:22][CH:21]=3)([C:12]([F:15])([F:14])[F:13])[C:6]=2[CH:28]=1.CCCCCC>CC(O)C>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[NH:10][C:9](=[O:11])[O:8][C@@:7]([CH2:16][CH2:17][NH:18][C:19](=[O:27])[C:20]3[CH:25]=[CH:24][C:23]([F:26])=[CH:22][CH:21]=3)([C:12]([F:15])([F:14])[F:13])[C:6]=2[CH:28]=1

Participants

4

Reactant 2

HCID 8058HexaneHCID 68487153HCID 68487153, compound

Product 1

HCID 68490657HCID 68490657, compound

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

N-{2-[6-chloro-2-oxo-4-(trifluoromethyl)-1,4-dihydro-2H-3,1-benzoxazin-4-yl]ethyl}-4-fluorobenzamide was subjected to optical resolution by HPLC (Chiralpack AD-H, n-hexane:2-propanol=3:1), and a fraction eluted at a later time was concentrated, whereby the objective compound was obtained.

Workup

  1. washa fraction eluted at a later time
  2. concentrationwas concentrated
  3. customwhereby the objective compound was obtained

Sources & evidence

ORD record
ord-2c15152a3c264421b4eddb0c5c450125
Source dataset
uspto-grants-2012_11
Patent number
US08314094B2

Reaction notes

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