Hexane → HCID 68489870, compound

HRID 1878003Notes

Reaction equation

HRID 1878003 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[NH:10][C:9](=[O:11])[O:8][C:7]([CH2:16][CH2:17][CH2:18][NH:19][C:20](=[O:28])[C:21]3[CH:26]=[CH:25][C:24]([F:27])=[CH:23][CH:22]=3)([C:12]([F:15])([F:14])[F:13])[C:6]=2[CH:29]=1.CCCCCC>CC(O)C>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[NH:10][C:9](=[O:11])[O:8][C@@:7]([CH2:16][CH2:17][CH2:18][NH:19][C:20](=[O:28])[C:21]3[CH:22]=[CH:23][C:24]([F:27])=[CH:25][CH:26]=3)([C:12]([F:15])([F:14])[F:13])[C:6]=2[CH:29]=1

Participants

4

Reactant 2

HCID 8058HexaneHCID 25254566HCID 25254566, compound

Product 1

HCID 68489870HCID 68489870, compound

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

N-{3-[6-chloro-2-oxo-4-(trifluoromethyl)-1,4-dihydro-2H-3,1-benzoxazin-4-yl]propyl}-4-fluorobenzamide was subjected to optical resolution by HPLC (Chiralpack AD-H, n-hexane:2-propanol=3:1), and a fraction eluted at a later time was concentrated, whereby the objective compound was obtained.

Workup

  1. washa fraction eluted at a later time
  2. concentrationwas concentrated
  3. customwhereby the objective compound was obtained

Sources & evidence

ORD record
ord-c143c707e47941c18dd538cadda1298b
Source dataset
uspto-grants-2012_11
Patent number
US08314094B2

Reaction notes

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