Hexane → HCID 68491678, compound

HRID 1878007Notes

Reaction equation

HRID 1878007 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[NH:10][C:9](=[O:11])[O:8][C:7]([CH2:16][CH2:17][CH2:18][NH:19][S:20]([C:23]3[CH:28]=[CH:27][CH:26]=[CH:25][N:24]=3)(=[O:22])=[O:21])([C:12]([F:15])([F:14])[F:13])[C:6]=2[CH:29]=1.CCCCCC>CC(O)C>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[NH:10][C:9](=[O:11])[O:8][C@@:7]([CH2:16][CH2:17][CH2:18][NH:19][S:20]([C:23]3[CH:28]=[CH:27][CH:26]=[CH:25][N:24]=3)(=[O:22])=[O:21])([C:12]([F:15])([F:14])[F:13])[C:6]=2[CH:29]=1

Participants

4

Reactant 2

HCID 8058HexaneHCID 25254721HCID 25254721, compound

Product 1

HCID 68491678HCID 68491678, compound

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

N-{3-[6-chloro-2-oxo-4-(trifluoromethyl)-1,4-dihydro-2H-3,1-benzoxazin-4-yl]propyl}pyridine-2-sulfonamide was subjected to optical resolution by HPLC (Chiralpack AD-H, n-hexane:2-propanol=3:2), and a fraction eluted at a later time was concentrated, whereby the objective compound was obtained.

Workup

  1. washa fraction eluted at a later time
  2. concentrationwas concentrated
  3. customwhereby the objective compound was obtained

Sources & evidence

ORD record
ord-e186ac07aa8742bead64328a95994780
Source dataset
uspto-grants-2012_11
Patent number
US08314094B2

Reaction notes

Loading…