Hexane → HCID 68488223, compound

HRID 1878030Notes

Reaction equation

HRID 1878030 reaction equation
[F:1][C:2]1[CH:31]=[CH:30][C:5]([C:6]([NH:8][CH2:9][C:10]2([C:26]([F:29])([F:28])[F:27])[C:15]3[CH:16]=[C:17]([N:20]4[CH:24]=[CH:23][CH:22]=[N:21]4)[CH:18]=[CH:19][C:14]=3[NH:13][C:12](=[O:25])[O:11]2)=[O:7])=[CH:4][CH:3]=1.CCCCCC>C(O)C>[F:1][C:2]1[CH:31]=[CH:30][C:5]([C:6]([NH:8][CH2:9][C@:10]2([C:26]([F:28])([F:27])[F:29])[C:15]3[CH:16]=[C:17]([N:20]4[CH:24]=[CH:23][CH:22]=[N:21]4)[CH:18]=[CH:19][C:14]=3[NH:13][C:12](=[O:25])[O:11]2)=[O:7])=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 8058HexaneHCID 44550274HCID 44550274, compound

Product 1

HCID 68488223HCID 68488223, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

4-Fluoro-N-{[2-oxo-6-(1H-pyrazol-1-yl)-4-(trifluoromethyl)-1,4-dihydro-2H-3,1-benzoxazin-4-yl]methyl}benzamide was subjected to optical resolution by HPLC (Chiralpack AD-H, n-hexane:ethanol=4:1), and a fraction eluted at a later time was concentrated, whereby the objective compound was obtained.

Workup

  1. washa fraction eluted at a later time
  2. concentrationwas concentrated
  3. customwhereby the objective compound was obtained

Sources & evidence

ORD record
ord-e39b8b9761a34352b647510073415f47
Source dataset
uspto-grants-2012_11
Patent number
US08314094B2

Reaction notes

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