HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hexane → HCID 68489309, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hexane | HCID 8058 | — |
| Reactant | HCID 25254565 | HCID 25254565 | — |
| Solvent | Isopropanol | HCID 3776 | — |
| Product | HCID 68489309 | HCID 68489309 | — |
Reaction Steps
N-{[6-chloro-2-oxo-4-(trifluoromethyl)-1,2,3,4-tetrahydroquinazolin-4-yl]methyl}4-fluorobenzamide was subjected to optical resolution by HPLC (Chiralpack AD-H, n-hexane:2-propanol=3:1), and a fraction eluted at a later time was concentrated, whereby the objective compound was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08314094B2 |
| Source dataset | uspto-grants-2012_11 |
| ORD ID | ord-dbe9a8c2cbdf4b6494ae9265cad0653e |
| Source note | uspto-grants-2012_11 |