Hexane → HCID 68489309, compound

HRID 1878036Notes

Reaction equation

HRID 1878036 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[NH:8][C:7](=[O:12])[NH:6][C:5]2([CH2:17][NH:18][C:19](=[O:27])[C:20]1[CH:25]=[CH:24][C:23]([F:26])=[CH:22][CH:21]=1)[C:13]([F:16])([F:15])[F:14].CCCCCC>CC(O)C>[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[NH:8][C:7](=[O:12])[NH:6][C@@:5]2([CH2:17][NH:18][C:19](=[O:27])[C:20]1[CH:21]=[CH:22][C:23]([F:26])=[CH:24][CH:25]=1)[C:13]([F:16])([F:14])[F:15]

Participants

4

Reactant 2

HCID 8058HexaneHCID 25254565HCID 25254565, compound

Product 1

HCID 68489309HCID 68489309, compound

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

N-{[6-chloro-2-oxo-4-(trifluoromethyl)-1,2,3,4-tetrahydroquinazolin-4-yl]methyl}4-fluorobenzamide was subjected to optical resolution by HPLC (Chiralpack AD-H, n-hexane:2-propanol=3:1), and a fraction eluted at a later time was concentrated, whereby the objective compound was obtained.

Workup

  1. washa fraction eluted at a later time
  2. concentrationwas concentrated
  3. customwhereby the objective compound was obtained

Sources & evidence

ORD record
ord-dbe9a8c2cbdf4b6494ae9265cad0653e
Source dataset
uspto-grants-2012_11
Patent number
US08314094B2

Reaction notes

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