Potassium Hydroxide → HCID 137068883, compound

HRID 1878050Notes

Reaction equation

HRID 1878050 reaction equation
Cl.[NH2:2][OH:3].[OH-].[K+].[Cl:6][CH2:7][C:8]([NH:10][C:11]1[CH:12]=[N:13][C:14]([C:17]#[N:18])=[CH:15][CH:16]=1)=[O:9]>CO>[Cl:6][CH2:7][C:8]([NH:10][C:11]1[CH:12]=[N:13][C:14]([C:17](=[N:2][OH:3])[NH2:18])=[CH:15][CH:16]=1)=[O:9]

Participants

5

Reactant 3

HCID 14797Potassium HydroxideHCID 443297Hydroxyamine hydrochlorideHCID 44574259HCID 44574259, compound

Product 1

HCID 137068883HCID 137068883, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Hydroxylamine hydrochloride (0.16 g, 2.3 mmol) was added to a solution of potassium hydroxide (0.152 g, 2.3 mmol) in methanol and the mixture was stirred for 30 minutes and filtered. To the filtrate, compound of example 3 (0.3 g, 1.53 mmol) was added and reaction mixture was refluxed for 4 hours. After completion of reaction the mixture was cooled, concentrated and triturated with diethyl ether to obtain the title compound.

Workup

  1. filtrationfiltered
  2. customreaction mixture
  3. temperaturewas refluxed for 4 hours
  4. customAfter completion of reaction the mixture
  5. temperaturewas cooled
  6. concentrationconcentrated
  7. customtriturated with diethyl ether

Sources & evidence

ORD record
ord-c404df0c24084c34841264fc935271b0
Source dataset
uspto-grants-2012_11
Patent number
US08314103B2

Reaction notes

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