Succinic anhydride → HCID 25184711, compound

HRID 1878067Notes

Reaction equation

HRID 1878067 reaction equation
[Cl:1][CH2:2][C:3]([NH:5][C:6]1[CH:7]=[N:8][C:9]([C:12](=[N:14][OH:15])[NH2:13])=[CH:10][CH:11]=1)=[O:4].[C:16]1(=O)[O:21][C:19](=[O:20])[CH2:18][CH2:17]1>CN(C)C=O.O>[Cl:1][CH2:2][C:3]([NH:5][C:6]1[CH:11]=[CH:10][C:9]([C:12]2[N:13]=[C:16]([CH2:17][CH2:18][C:19]([OH:21])=[O:20])[O:15][N:14]=2)=[N:8][CH:7]=1)=[O:4]

Participants

5

Reactant 2

HCID 7922Succinic anhydrideHCID 137068883HCID 137068883, compound

Product 1

HCID 25184711HCID 25184711, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 6228DimethylformamideSolvent

Procedure

A mixture of compound of example 4 (0.228 g, 1 mmol) and succinic anhydride was stirred in dimethyl formamide (5 mL), at a temperature in the range of 115-120° C. for a period of 16 hours. The reaction mixture was cooled, diluted with water, and extracted with ethyl acetate (3×50 mL). The organic layer was washed with brine, dried over sodium sulfate and concentrated. The crude product obtained was purified over silica gel using ethyl acetate as eluent. The pure fractions were concentrated and crystallized using ethyl acetate/petroleum ether, to obtain the title compound.

Workup

  1. temperatureThe reaction mixture was cooled
  2. extractionextracted with ethyl acetate (3×50 mL)
  3. washThe organic layer was washed with brine
  4. dry with materialdried over sodium sulfate
  5. concentrationconcentrated
  6. customThe crude product obtained
  7. customwas purified over silica gel
  8. concentrationThe pure fractions were concentrated
  9. customcrystallized

Sources & evidence

ORD record
ord-9bc711ea67764b76a5c43d62405644d9
Source dataset
uspto-grants-2012_11
Patent number
US08314103B2

Reaction notes

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