1-(2-Pyridyl)piperazine → HCID 11675339, compound

HRID 1878116Notes

Reaction equation

HRID 1878116 reaction equation
[F:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[C:7]([O:12][CH3:13])[C:6]([NH:14][C:15](=[O:19])OCC)=[N:5]2.[N:20]1[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=1[N:26]1[CH2:31][CH2:30][NH:29][CH2:28][CH2:27]1>>[F:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[C:7]([O:12][CH3:13])[C:6]([NH:14][C:15]([N:29]1[CH2:30][CH2:31][N:26]([C:21]3[CH:22]=[CH:23][CH:24]=[CH:25][N:20]=3)[CH2:27][CH2:28]1)=[O:19])=[N:5]2

Participants

3

Reactant 2

HCID 944591-(2-Pyridyl)piperazineHCID 66917965Ethyl N-(6-fluoro-2-methoxyquinoxalin-3-yl)carbamate

Product 1

HCID 11675339HCID 11675339, compoundYield 79%

Procedure

Ethyl N-(6-fluoro-2-methoxyquinoxalin-3-yl)carbamate and 1-(2-pyridyl)piperazine were reacted by the same way with the example 1 to obtain the titled compound (yield, 79%). 1H NMR (200 MHz, CDCl3): δ 3.71 (s, 7H), 4.11 (s, 4H), 6.66 (d, J=9.0 Hz, 2H), 7.10 (m, 1H), 7.22-7.25 (m, 1H), 7.38-7.54 (m, 3H), 7.65-7.68 (m, 1H), 8.19 (d, J=3.8 Hz, 1H).

Sources & evidence

ORD record
ord-5e8759863a4a4c1aa8d64f10cdcf77a4
Source dataset
uspto-grants-2012_11
Patent number
US08314100B2

Reaction notes

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