N-(2-Cyanophenyl)piperazine → 1-[(2-Methoxy-6-methylquinoxalin-3-yl)aminocarbonyl]-4-(2-cyanophenyl)piperazine

HRID 1878157노트

반응식

HRID 1878157 반응식
[CH3:1][O:2][C:3]1[C:12]([NH:13][C:14](=[O:18])OCC)=[N:11][C:10]2[C:5](=[CH:6][CH:7]=[C:8]([CH3:19])[CH:9]=2)[N:4]=1.[C:20]([C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][C:23]=1[N:28]1[CH2:33][CH2:32][NH:31][CH2:30][CH2:29]1)#[N:21]>>[CH3:1][O:2][C:3]1[C:12]([NH:13][C:14]([N:31]2[CH2:30][CH2:29][N:28]([C:23]3[CH:24]=[CH:25][CH:26]=[CH:27][C:22]=3[C:20]#[N:21])[CH2:33][CH2:32]2)=[O:18])=[N:11][C:10]2[C:5](=[CH:6][CH:7]=[C:8]([CH3:19])[CH:9]=2)[N:4]=1

참가 물질

3

반응물 2

HCID 2735875N-(2-Cyanophenyl)piperazineHCID 66917958Ethyl N-(2-methoxy-6-methylquinoxalin-3-yl)carbamate

생성물 1

HCID 669182451-[(2-Methoxy-6-methylquinoxalin-3-yl)aminocarbonyl]-4-(2-cyanophenyl)piperazine수율 91%

실험 절차

Ethyl N-(2-methoxy-6-methylquinoxalin-3-yl)carbamate and 1-(2-cyanophenyl)piperazine were reacted by the same way with the example 43 to obtain the titled compound (yield, 91%). 1H NMR (300 MHz, CDCl3): δ 2.46 (s, 3H), 3.28 (s, 4H), 3.86 (s, 3H), 4.08-4.19 (m, 4H), 7.01-7.08 (m, 3H), 7.17-7.37 (m, 1H), 7.49-7.61 (m, 4H).

출처 및 근거

ORD 기록
ord-8904e34f177d49fba80899dd7bbc6d66
출처 데이터셋
uspto-grants-2012_11
특허 번호
US08314100B2

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