1-(3,5-Dimethylphenyl)piperazine → HCID 52948333, compound

HRID 1878172Notes

Reaction equation

HRID 1878172 reaction equation
[CH3:1][O:2][C:3]1[C:12]([NH:13][C:14](=[O:18])OCC)=[N:11][C:10]2[C:5](=[CH:6][CH:7]=[C:8]([O:19][CH3:20])[CH:9]=2)[N:4]=1.[CH3:21][C:22]1[CH:23]=[C:24]([N:29]2[CH2:34][CH2:33][NH:32][CH2:31][CH2:30]2)[CH:25]=[C:26]([CH3:28])[CH:27]=1>>[CH3:1][O:2][C:3]1[C:12]([NH:13][C:14]([N:32]2[CH2:33][CH2:34][N:29]([C:24]3[CH:25]=[C:26]([CH3:28])[CH:27]=[C:22]([CH3:21])[CH:23]=3)[CH2:30][CH2:31]2)=[O:18])=[N:11][C:10]2[C:5](=[CH:6][CH:7]=[C:8]([O:19][CH3:20])[CH:9]=2)[N:4]=1

Participants

3

Reactant 2

HCID 27586261-(3,5-Dimethylphenyl)piperazineHCID 66918080Ethyl N-(2,6-dimethoxyquinoxalin-3-yl)carbamate

Product 1

HCID 52948333HCID 52948333, compoundYield 65%

Procedure

Ethyl N-(2,6-dimethoxyquinoxalin-3-yl)carbamate and 1-(3,5-dimethylphenyl)piperazine were reacted by the same way with the example 64 to obtain the titled compound (yield, 65%). 1H NMR (300 MHz, CDCl3): δ 2.28 (s, 6H), 3.26 (s, 4H), 3.76-3.87 (m, 6H), 4.11 (s, 4H), 6.59 (s, 2H), 6.90 (m, 1H), 7.14 (d, J=8.7 Hz, 1H), 7.32 (s, 1H), 7.51 (d, J=7.5 Hz, 1H), 7.64 (d, J=8.7 Hz, 1H).

Sources & evidence

ORD record
ord-a248813f70f84590934c9b53df2d5d4f
Source dataset
uspto-grants-2012_11
Patent number
US08314100B2

Reaction notes

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