N-(2-Cyanophenyl)piperazine → HCID 66918223, compound

HRID 1878178Notes

Reaction equation

HRID 1878178 reaction equation
[CH3:1][O:2][C:3]1[C:12]([NH:13][C:14](=[O:18])OCC)=[N:11][C:10]2[C:5](=[CH:6][CH:7]=[C:8]([O:19][CH3:20])[CH:9]=2)[N:4]=1.[C:21]([C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][C:24]=1[N:29]1[CH2:34][CH2:33][NH:32][CH2:31][CH2:30]1)#[N:22]>>[CH3:1][O:2][C:3]1[C:12]([NH:13][C:14]([N:32]2[CH2:31][CH2:30][N:29]([C:24]3[CH:25]=[CH:26][CH:27]=[CH:28][C:23]=3[C:21]#[N:22])[CH2:34][CH2:33]2)=[O:18])=[N:11][C:10]2[C:5](=[CH:6][CH:7]=[C:8]([O:19][CH3:20])[CH:9]=2)[N:4]=1

Participants

3

Reactant 2

HCID 2735875N-(2-Cyanophenyl)piperazineHCID 66918080Ethyl N-(2,6-dimethoxyquinoxalin-3-yl)carbamate

Product 1

HCID 66918223HCID 66918223, compoundYield 94%

Procedure

Ethyl N-(2,6-dimethoxyquinoxalin-3-yl)carbamate and 1-(2-cyanophenyl)piperazine were reacted by the same way with the example 64 to obtain the titled compound (yield, 94%). 1H NMR (200 MHz, CDCl3): δ 3.30 (s, 4H), 3.88-3.90 (m, 6H), 4.07-4.20 (m, 4H), 6.94-7.07 (m, 3H), 7.27-7.34 (m, 2H), 7.53-7.63 (m, 3H).

Sources & evidence

ORD record
ord-0d983070e0b94fc28bdb456db3b8d34d
Source dataset
uspto-grants-2012_11
Patent number
US08314100B2

Reaction notes

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