1-(4-Chlorophenyl)piperazine → HCID 69242561, compound

HRID 1878200Notes

Reaction equation

HRID 1878200 reaction equation
[F:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[C:7]([NH:12][C:13](=[O:17])OCC)[C:6]([O:18][CH3:19])=[N:5]2.[Cl:20][C:21]1[CH:26]=[CH:25][C:24]([N:27]2[CH2:32][CH2:31][NH:30][CH2:29][CH2:28]2)=[CH:23][CH:22]=1>>[F:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[C:7]([NH:12][C:13]([N:30]1[CH2:29][CH2:28][N:27]([C:24]3[CH:23]=[CH:22][C:21]([Cl:20])=[CH:26][CH:25]=3)[CH2:32][CH2:31]1)=[O:17])[C:6]([O:18][CH3:19])=[N:5]2

Participants

3

Reactant 2

HCID 974781-(4-Chlorophenyl)piperazineHCID 69243333ethyl N-(6-fluoro-3-methoxyquinoxalin-2-yl)carbamate

Product 1

HCID 69242561HCID 69242561, compoundYield 86%

Procedure

Ethyl N-(6-fluoro-3-methoxyquinoxalin-2-yl)carbamate and 1-(4-chlorophenyl)piperazine were reacted by the same way with the example 85 to obtain the titled compound (yield, 86%). 1H NMR (300 MHz, CDCl3): δ 3.24-3.27 (m, 4H), 3.74-3.77 (m, 4H), 4.15 (s, 3H), 6.84-6.89 (m, 2H), 7.14-7.43 (m, 5H), 7.77-7.82 (m, 1H).

Sources & evidence

ORD record
ord-0ccf132b610e4f1ab5192df1d7b84347
Source dataset
uspto-grants-2012_11
Patent number
US08314100B2

Reaction notes

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