HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(2-Pyridyl)piperazine → 1-[(6-Fluoro-3-methoxyquinoxalin-2-yl)aminocarbonyl]-4-(2-pyridyl)piperazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(2-Pyridyl)piperazine | HCID 94459 | — |
| Reactant | ethyl N-(6-fluoro-3-methoxyquinoxalin-2-yl)carbamate | HCID 69243333 | — |
| Product | 1-[(6-Fluoro-3-methoxyquinoxalin-2-yl)aminocarbonyl]-4-(2-pyridyl)piperazine | HCID 69243655 | 80% |
Reaction Steps
Ethyl N-(6-fluoro-3-methoxyquinoxalin-2-yl)carbamate and 1-(2-pyridyl)piperazine were reacted by the same way with the example 85 to obtain the titled compound (yield, 80%). 1H NMR (200 MHz, CDCl3): δ 3.72-3.76 (m, 8H), 4.16 (s, 3H), 6.66-6.70 (m, 2H), 7.24-7.52 (m, 4H), 7.80-7.81 (m, 1H), 8.21 (dd, J=5.4 and 1.8 Hz, 1H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08314100B2 |
| Source dataset | uspto-grants-2012_11 |
| ORD ID | ord-22e4d4cb7f5f487295c46a809837a223 |
| Source note | uspto-grants-2012_11 |