1-(2-Pyridyl)piperazine → 1-[(6-Fluoro-3-methoxyquinoxalin-2-yl)aminocarbonyl]-4-(2-pyridyl)piperazine

HRID 1878204Notes

Reaction equation

HRID 1878204 reaction equation
[F:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[C:7]([NH:12][C:13](=[O:17])OCC)[C:6]([O:18][CH3:19])=[N:5]2.[N:20]1[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=1[N:26]1[CH2:31][CH2:30][NH:29][CH2:28][CH2:27]1>>[F:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[C:7]([NH:12][C:13]([N:29]1[CH2:30][CH2:31][N:26]([C:21]3[CH:22]=[CH:23][CH:24]=[CH:25][N:20]=3)[CH2:27][CH2:28]1)=[O:17])[C:6]([O:18][CH3:19])=[N:5]2

Participants

3

Reactant 2

HCID 944591-(2-Pyridyl)piperazineHCID 69243333ethyl N-(6-fluoro-3-methoxyquinoxalin-2-yl)carbamate

Product 1

HCID 692436551-[(6-Fluoro-3-methoxyquinoxalin-2-yl)aminocarbonyl]-4-(2-pyridyl)piperazineYield 80%

Procedure

Ethyl N-(6-fluoro-3-methoxyquinoxalin-2-yl)carbamate and 1-(2-pyridyl)piperazine were reacted by the same way with the example 85 to obtain the titled compound (yield, 80%). 1H NMR (200 MHz, CDCl3): δ 3.72-3.76 (m, 8H), 4.16 (s, 3H), 6.66-6.70 (m, 2H), 7.24-7.52 (m, 4H), 7.80-7.81 (m, 1H), 8.21 (dd, J=5.4 and 1.8 Hz, 1H).

Sources & evidence

ORD record
ord-22e4d4cb7f5f487295c46a809837a223
Source dataset
uspto-grants-2012_11
Patent number
US08314100B2

Reaction notes

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