1-(2-Pyrimidinyl)piperazine → HCID 69242587, compound

HRID 1878205Notes

Reaction equation

HRID 1878205 reaction equation
[F:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[C:7]([NH:12][C:13](=[O:17])OCC)[C:6]([O:18][CH3:19])=[N:5]2.[N:20]1[CH:25]=[CH:24][CH:23]=[N:22][C:21]=1[N:26]1[CH2:31][CH2:30][NH:29][CH2:28][CH2:27]1>>[F:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[C:7]([NH:12][C:13]([N:29]1[CH2:30][CH2:31][N:26]([C:21]3[N:20]=[CH:25][CH:24]=[CH:23][N:22]=3)[CH2:27][CH2:28]1)=[O:17])[C:6]([O:18][CH3:19])=[N:5]2

Participants

3

Reactant 2

HCID 887471-(2-Pyrimidinyl)piperazineHCID 69243333ethyl N-(6-fluoro-3-methoxyquinoxalin-2-yl)carbamate

Product 1

HCID 69242587HCID 69242587, compoundYield 79%

Procedure

Ethyl N-(6-fluoro-3-methoxyquinoxalin-2-yl)carbamate and 1-(2-pyrimidyl)piperazine were reacted by the same way with the example 85 to obtain the titled compound (yield, 79%). 1H NMR (200 MHz, CDCl3): δ 3.69 (s, 4H), 3.98 (s, 4H), 4.14 (s, 3H), 6.54 (t, J=4.8 Hz, 1H), 7.21-7.41 (m, 3H), 7.79 (t, J=8.4 Hz, 1H), 8.34 (d, J=4.8 Hz, 2H).

Sources & evidence

ORD record
ord-d45f439e69124d6b957e131f0601ba7e
Source dataset
uspto-grants-2012_11
Patent number
US08314100B2

Reaction notes

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