1-(4-Fluorophenyl)piperazine → HCID 69242043, compound

HRID 1878220Notes

Reaction equation

HRID 1878220 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[C:7]([NH:12][C:13](=[O:17])OCC)[C:6]([O:18][CH3:19])=[N:5]2.[F:20][C:21]1[CH:26]=[CH:25][C:24]([N:27]2[CH2:32][CH2:31][NH:30][CH2:29][CH2:28]2)=[CH:23][CH:22]=1>>[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[C:7]([NH:12][C:13]([N:30]1[CH2:29][CH2:28][N:27]([C:24]3[CH:23]=[CH:22][C:21]([F:20])=[CH:26][CH:25]=3)[CH2:32][CH2:31]1)=[O:17])[C:6]([O:18][CH3:19])=[N:5]2

Participants

3

Reactant 2

HCID 752601-(4-Fluorophenyl)piperazineHCID 69241674ethyl N-(6-chloro-3-methoxyquinoxalin-2-yl)carbamate

Product 1

HCID 69242043HCID 69242043, compoundYield 88%

Procedure

Ethyl N-(6-chloro-3-methoxyquinoxalin-2-yl)carbamate and 1-(4-fluorophenyl)piperazine were reacted by the same way with the example 106 to obtain the titled compound (yield, 88%). 1H NMR (300 MHz, CDCl3): δ 3.19-3.22 (m, 4H), 3.75-3.78 (m, 4H), 4.16 (s, 3H), 6.89-6.93 (m, 4H), 7.29-7.46 (m, 2H), 7.74-7.76 (m, 1H).

Sources & evidence

ORD record
ord-b0183559bffd4b7d8ae878b4c73ed0e2
Source dataset
uspto-grants-2012_11
Patent number
US08314100B2

Reaction notes

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