1-(4-Chlorophenyl)piperazine → HCID 69242558, compound

HRID 1878223Notes

Reaction equation

HRID 1878223 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[C:7]([NH:12][C:13](=[O:17])OCC)[C:6]([O:18][CH3:19])=[N:5]2.[Cl:20][C:21]1[CH:26]=[CH:25][C:24]([N:27]2[CH2:32][CH2:31][NH:30][CH2:29][CH2:28]2)=[CH:23][CH:22]=1>>[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[C:7]([NH:12][C:13]([N:30]1[CH2:29][CH2:28][N:27]([C:24]3[CH:23]=[CH:22][C:21]([Cl:20])=[CH:26][CH:25]=3)[CH2:32][CH2:31]1)=[O:17])[C:6]([O:18][CH3:19])=[N:5]2

Participants

3

Reactant 2

HCID 974781-(4-Chlorophenyl)piperazineHCID 69241674ethyl N-(6-chloro-3-methoxyquinoxalin-2-yl)carbamate

Product 1

HCID 69242558HCID 69242558, compoundYield 94%

Procedure

Ethyl N-(6-chloro-3-methoxyquinoxalin-2-yl)carbamate and 1-(4-chlorophenyl)piperazine were reacted by the same way with the example 106 to obtain the titled compound (yield, 94%). 1H NMR (300 MHz, CDCl3): δ 3.25 (s, 4H), 3.76 (s, 4H), 4.15 (s, 3H), 6.86 (d, J=9.0 Hz, 2H), 7.22-7.45 (m, 4H), 7.72-7.75 (m, 2H).

Sources & evidence

ORD record
ord-1484fc1c58764031b84d2352ca5f2063
Source dataset
uspto-grants-2012_11
Patent number
US08314100B2

Reaction notes

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