1-(2-Pyridyl)piperazine → HCID 69244048, compound

HRID 1878227Notes

Reaction equation

HRID 1878227 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[C:7]([NH:12][C:13](=[O:17])OCC)[C:6]([O:18][CH3:19])=[N:5]2.[N:20]1[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=1[N:26]1[CH2:31][CH2:30][NH:29][CH2:28][CH2:27]1>>[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[C:7]([NH:12][C:13]([N:29]1[CH2:30][CH2:31][N:26]([C:21]3[CH:22]=[CH:23][CH:24]=[CH:25][N:20]=3)[CH2:27][CH2:28]1)=[O:17])[C:6]([O:18][CH3:19])=[N:5]2

Participants

3

Reactant 2

HCID 944591-(2-Pyridyl)piperazineHCID 69241674ethyl N-(6-chloro-3-methoxyquinoxalin-2-yl)carbamate

Product 1

HCID 69244048HCID 69244048, compoundYield 87%

Procedure

Ethyl N-(6-chloro-3-methoxyquinoxalin-2-yl)carbamate and 1-(2-pyridyl)piperazine were reacted by the same way with the example 106 to obtain the titled compound (yield, 87%). 1H NMR (300 MHz, CDCl3): δ 3.73 (m, 8H), 4.15 (s, 3H), 6.68 (d, J=8.4 Hz, 2H), 7.11-7.76 (m, 5H), 8.21 (dd, J=3.6 and 0.6 Hz, 1H).

Sources & evidence

ORD record
ord-0ca677ef81464ae39bc87284692b7325
Source dataset
uspto-grants-2012_11
Patent number
US08314100B2

Reaction notes

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