HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(4-Nitrophenyl)piperazine → 1-[(3,6-Dimethoxyquinoxalin-2-yl)aminocarbonyl]-4-(4-nitrophenyl)piperazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(4-Nitrophenyl)piperazine | HCID 80447 | — |
| Reactant | ethyl N-(3,6-dimethoxyquinoxalin-2-yl)carbamate | HCID 69244324 | — |
| Product | 1-[(3,6-Dimethoxyquinoxalin-2-yl)aminocarbonyl]-4-(4-nitrophenyl)piperazine | HCID 69244454 | 94% |
Reaction Steps
Ethyl N-(3,6-dimethoxyquinoxalin-2-yl)carbamate and 1-(4-nitrophenyl)piperazine were reacted by the same way with the example 148 to obtain the titled compound (yield, 94%). 1H NMR (300 MHz, CDCl3): δ 3.57-3.65 (m, 8H), 3.90 (s, 3H), 4.01 (s, 3H), 7.06 (d, J=9.4 Hz, 2H), 7.18-7.22 (m, 2H), 7.69 (d, J=8.6 Hz, 2H), 8.09 (d, J=9.4 Hz, 2H), 9.20 (s, 1H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08314100B2 |
| Source dataset | uspto-grants-2012_11 |
| ORD ID | ord-f5561589d5c34d8f8e4c87ab0b2d38e7 |
| Source note | uspto-grants-2012_11 |