1-(2-Pyrimidinyl)piperazine → HCID 69243596, compound

HRID 1878273Notes

Reaction equation

HRID 1878273 reaction equation
[CH3:1][O:2][C:3]1[C:4]([NH:15][C:16](=[O:20])OCC)=[N:5][C:6]2[C:11]([N:12]=1)=[CH:10][C:9]([O:13][CH3:14])=[CH:8][CH:7]=2.[N:21]1[CH:26]=[CH:25][CH:24]=[N:23][C:22]=1[N:27]1[CH2:32][CH2:31][NH:30][CH2:29][CH2:28]1>>[CH3:1][O:2][C:3]1[C:4]([NH:15][C:16]([N:30]2[CH2:31][CH2:32][N:27]([C:22]3[N:21]=[CH:26][CH:25]=[CH:24][N:23]=3)[CH2:28][CH2:29]2)=[O:20])=[N:5][C:6]2[C:11]([N:12]=1)=[CH:10][C:9]([O:13][CH3:14])=[CH:8][CH:7]=2

Participants

3

Reactant 2

HCID 887471-(2-Pyrimidinyl)piperazineHCID 69244324ethyl N-(3,6-dimethoxyquinoxalin-2-yl)carbamate

Product 1

HCID 69243596HCID 69243596, compoundYield 86%

Procedure

Ethyl N-(3,6-dimethoxyquinoxalin-2-yl)carbamate and 1-(2-pyrimidyl)piperazine were reacted by the same way with the example 148 to obtain the titled compound (yield, 86%). 1H NMR (300 MHz, CDCl3): δ 3.67-3.70 (m, 4H), 3.90 (s, 3H), 3.95-3.97 (m, 4H), 4.13 (s, 3H), 6.53 (t, J=4.8 Hz, 1H), 7.11-7.23 (m, 4H), 7.30 (d, J=9.3 Hz, 1H), 8.33 (d, J=4.8 Hz, 2H).

Sources & evidence

ORD record
ord-6a76c0e51a0044779d9debb68ddfc244
Source dataset
uspto-grants-2012_11
Patent number
US08314100B2

Reaction notes

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