HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triphenylphosphine → HCID 58305827, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triphenylphosphine | HCID 11776 | — |
| Reactant | 1-(2-Hydroxy-6-methoxyphenyl)ethan-1-one | HCID 69709 | — |
| Reactant | Diisopropyl diazene-1,2-dicarboxylate | HCID 75555 | — |
| Reactant | tert-butyl N-(3-hydroxypropyl)carbamate | HCID 3838134 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 58305827 | HCID 58305827 | 42.3% |
Reaction Steps
Diisopropyl azodicarboxylate (2.82 g, 14.0 mmol) is added to a stirred solution of tert-butyl 3-hydroxypropylcarbamate (2.45 g, 14.0 mmol), 1-(2-hydroxy-6-methoxyphenyl)ethanone (1.94 g, 11.7 mmol) and triphenylphosphine (3.66 g, 14.0 mmol) in THF (50 mL) at room temperature. After stirring for 18 h, the solvent is removed under reduced pressure and the crude product is chromatographed (hexane-ethyl acetate: 0-60% gradient) to afford 1.60 g of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08314108B2 |
| Source dataset | uspto-grants-2012_11 |
| ORD ID | ord-782a9eba264e470cb4e98501c790c276 |
| Source note | uspto-grants-2012_11 |