反应详情

Diisopropyl azodicarboxylate (2.82 g, 14.0 mmol) is added to a stirred solution of tert-butyl 3-hydroxypropylcarbamate (2.45 g, 14.0 mmol), 1-(2-hydroxy-6-methoxyphenyl)ethanone (1.94 g, 11.7 mmol) and triphenylphosphine (3.66 g, 14.0 mmol) in THF (50 mL) at room temperature. After stirring for 18 h, the solvent is removed under reduced pressure and the crude product is chromatographed (hexane-ethyl acetate: 0-60% gradient) to afford 1.60 g of the title compound.

1. customthe solvent is removed under reduced pressure
2. customthe crude product is chromatographed (hexane-ethyl acetate: 0-60% gradient)