Hydrochloric Acid → 3-((4-(4-Amino-2-chlorobenzoyl)piperazin-1-yl)methyl)-N-tert-butylbenzamide

関与物質

反応手順

N-tert-Butyl-3-((4-(2-chloro-4-nitrobenzoyl)piperazin-1-yl)methyl)benzamide (1.9483 g, 4.2 mmol) was added to a suspension of reduced iron powder (2.3623 g, 42 mmol) and 1M hydrochloric acid (6 mL) in isopropanol. The reaction was stirred at room temperature for 2 hours. The reaction was concentrated under reduced pressure and the remaining residue was taken up in dichloromethane and washed with water. The organic phase was dried over magnesium sulphate and concentrated under vacuum to afford the title compound (1.57 g).

情報源と証拠