反应详情

N-tert-Butyl-3-((4-(2-chloro-4-nitrobenzoyl)piperazin-1-yl)methyl)benzamide (1.9483 g, 4.2 mmol) was added to a suspension of reduced iron powder (2.3623 g, 42 mmol) and 1M hydrochloric acid (6 mL) in isopropanol. The reaction was stirred at room temperature for 2 hours. The reaction was concentrated under reduced pressure and the remaining residue was taken up in dichloromethane and washed with water. The organic phase was dried over magnesium sulphate and concentrated under vacuum to afford the title compound (1.57 g).

1. concentrationThe reaction was concentrated under reduced pressure
2. washwashed with water
3. dry with materialThe organic phase was dried over magnesium sulphate
4. concentrationconcentrated under vacuum