Phenyl isocyanate → HCID 57917619, compound

HRID 1878369Notes

Reaction equation

HRID 1878369 reaction equation
[NH2:1][C:2]1[CH:11]=[CH:10][C:5]([C:6]([O:8][CH3:9])=[O:7])=[CH:4][N:3]=1.[C:12]1([N:18]=[C:19]=[O:20])[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1>>[C:12]1([NH:18][C:19](=[O:20])[NH:1][C:2]2[CH:11]=[CH:10][C:5]([C:6]([O:8][CH3:9])=[O:7])=[CH:4][N:3]=2)[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1

Participants

3

Reactant 2

HCID 7672Phenyl isocyanateHCID 737487Methyl 6-aminonicotinate

Product 1

HCID 57917619HCID 57917619, compoundYield 104%

Conditions

Temperature
100 °C

Procedure

To a solution of methyl 6-aminonicotinate (500 mg, 3.29 mmol) in N,N-diemthylformamide (5 mL) was added phenyl isocyanate (358 μL, 3.29 mmol). The mixture was heated to 100° C. for 2 hours and was then concentrated under vacuum to give the title compound (928 mg).

Workup

  1. concentrationwas then concentrated under vacuum

Sources & evidence

ORD record
ord-94ad57d707064f3e8c411c87b033b174
Source dataset
uspto-grants-2012_11
Patent number
US08314091B2

Reaction notes

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