反应详情

温度

75 °C

A mixture of diethyl pyrazine-2,5-dicarboxylate (1.75 g, 7.81 mmol) and ethanol (15 mL) was heated to 75° C. to obtain a homogeneous solution. After cooling to room temperature, a solution of hydrazine monohydrate (0.281 g, 7.03 mmol) in ethanol (3.5 mL) was added to the solution dropwise over 4 hours. After stirring at room temperature overnight, a solid had precipitated out of the reaction mixture. The solid was collected by filtration and dried under vacuum to give the title compound (1.05 g).

1. customto obtain a homogeneous solution
2. temperatureAfter cooling to room temperature
3. customa solid had precipitated out of the reaction mixture
4. filtrationThe solid was collected by filtration
5. customdried under vacuum