反应详情

温度

5 °C

A mixture of ethyl 5-(hydrazinecarbonyl)pyrazine-2-carboxylate (1.00 g, 4.76 mmol), sodium nitrite (1.76 g, 25.5 mmol), water (18 mL) and dichloromethane (18 mL) was cooled to 0to 5° C. (ice-bath) under vigorous stirring. 6M hydrochloric acid (7.4 mL) was added drop-wise over 30 minutes, keeping the temperature under 10° C. After stirring for a further 30 minutes, the organic layer was separated, dried over magnesium sulfate and concentrated under vacuum to afford the title compound (1.01 g).

1. customunder 10° C
2. customthe organic layer was separated
3. dry with materialdried over magnesium sulfate
4. concentrationconcentrated under vacuum