Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | HCID 57917643 | HCID 57917643 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | HCID 57917691 | HCID 57917691 | 0.1% |
Reaction Steps
A mixture of tert-butyl 4-(1-(3-(tert-butylcarbamoyl)phenyl)-2-methylpropyl)piperazine-1-carboxylate (24 mg, 0,057 mmol) and 5M hydrochloric acid (0.20 mL) in 1,4-dioxane (2.0 mL) was stirred at 80° C. for 30 minutes. The reaction mixture was concentrated under vacuum and treated with strong cation exchange column chromatography to afford the title compound (13.6 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08314091B2 |
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| Source dataset | uspto-grants-2012_11 |
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| ORD ID | ord-649d16d99fca4da893880a639f4b2728 |
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| Source note | uspto-grants-2012_11 |
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