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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1878399Generated: November 4, 2026

Hydrochloric Acid → HCID 57917691, compound

https://huagongshe.com/reaction/1878399

Reaction equation

Participants

RoleNameHCIDCharge
ReactantHydrochloric AcidHCID 313—
ReactantHCID 57917643HCID 57917643—
Solvent1,4-DioxaneHCID 31275—
ProductHCID 57917691HCID 579176910.1%

Reaction Conditions

Temperature80 °C

Reaction Steps

A mixture of tert-butyl 4-(1-(3-(tert-butylcarbamoyl)phenyl)-2-methylpropyl)piperazine-1-carboxylate (24 mg, 0,057 mmol) and 5M hydrochloric acid (0.20 mL) in 1,4-dioxane (2.0 mL) was stirred at 80° C. for 30 minutes. The reaction mixture was concentrated under vacuum and treated with strong cation exchange column chromatography to afford the title compound (13.6 mg).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08314091B2
Source datasetuspto-grants-2012_11
ORD IDord-649d16d99fca4da893880a639f4b2728
Source noteuspto-grants-2012_11